张维民 博士

助理教授

2008-2012 中国农业大学，学士

2012-2018 365买球的网址，博士

2018-2023 纽约大学医学院，博士后

2023-2026 纽约大学医学院，研究助理教授

2026-至今 365买球的网址生科院，助理教授

2026-至今 清华-北大生命科学联合中心，研究员  

●  研究兴趣、领域：

自人类基因组测序完成以来，我们对基因组“读”的能力不断提升。然而，如何将海量基因组信息与人类疾病之间的相关性转化为因果性认识，并进一步发展精准治疗策略，仍是生命科学面临的重要挑战。

本实验室致力于开发新一代哺乳动物基因组编写与编辑技术，构建新型动物和细胞模型，重点解析基因组中大尺度调控元件及复杂基因组区域的功能。我们希望在更接近生理状态的模型中揭示人类疾病发生发展的分子机制，为疾病治疗提供新的理论基础和干预策略。

●  代表性论文：

1. Zhang, W.†, Zhao, Y., Prakash, P., Appleby, H.L., Barriball, K., Capponi, S., Jiang, Q., Wudzinska, A.M., Vaine, C.A., Ellis, G., Rahman, N., Markovic, S., Mishkit, O., Limberg, K.C., Maurano, M.T., Wadghiri, Y.Z., Kim, S.Y., Timmers, H.T.M., Bragg, D.C., Liddelow, S.A., Brosh, R.†, Boeke, J.D.†. Genome writing to dissect consequences of SVA retrotransposon disease X-Linked Dystonia Parkinsonism. Cell. (In press) († correspondence)

2. Zhang, W., Golynker, I., Brosh, R., Wudzinska, A.M., Zhu, Y., Carrau, L., Damani-Yokota, P., Khairallah, C., Chalhoub, N., Huang, E., Ashe, H., Khanna, K.M., Maurano, M.T., Kim, S.Y., tenOever, B.R., Boeke, J.D. Mouse genome rewriting and tailoring of three important disease loci. Nature. 2023.

3. Zhang, W.*, Zhao, G.*, Luo, Z.*, Lin, Y., Wang, L., Guo, Y., Wang, A., Jiang, S., Jiang, Q., Wang, Y., Hou, S., Huang, J., Li, T., Qin, Y., Dong, J., Qin, Q., Zhang, J., Zou, X., He, X., Zhao, L., Xiao, Y., Shen, Y., Kuang, Z., Mitchell, L., Yang, K., Richardson, S., Chen, G., Yuan, Y., Yang, H., Lin, J., Wu, Q., Bader, J., Cai, Y., Boeke, J., Dai, J. Engineering the ribosomal DNA in a megabase synthetic chromosome. Science. 2017. (*equal contribution)

4. Zhang, W., Lazar-Stefanita, L., Yamashita, H., Shen, M.J., Mitchell, L.A., Kurasawa, H., Haase, M.A.B., Sun, X., Jiang, Q., Lauer, S.L., McCulloch, L.H., Zhao, Y., Ichikawa, D., Easo, N., Lin, S.J., Fanfani, V., Camellato, B.R., Zhu, Y., Cai, J., Xu, Z., Build-A-Genome, Zeller, K., Bader, J.S., Stracquadanio, G., Deutsch, S., Aizawa, Y., Dai, J., Boeke, J.D. Manipulating the 3D organization of the largest synthetic yeast chromosome. Molecular Cell. 2023.

5. Zhang, W.*, Zhang, X.*, Xue, Z.*, Li, Y.*, Ma, Q., Ren, X., Zhang, J., Yang, S., Yang, L., Wu, M., Ren, M., Xi, R., Liu, J., Matunis, E., Dai, J., Gao, G. Probing the function of metazoan histones with a systematic library of H3 and H4 mutants. Developmental Cell. 2019. (*equal contribution)

6. Ordoñez, R.*, Zhang, W.*, Ellis, G., Zhu, F., Ashe, H.J., Ribeiro-dos-Santos, A.M., Brosh, R., Huang, E., Hogan, M.S., Boeke, J.D., Maurano M.T. Genomic context sensitizes regulatory elements to genetic disruption. Molecular Cell. 2024. (*equal contribution)

7. Schmauch, E.*, Piening, B.*, Mohebnasab M.*, Xia, B.*, Zhu, C.*, Stern, J.*, Zhang, W.*, Dowdell, A., Loza, B.-L., Mohebnasab, M., Gragert, L., et al. Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism Responses. Nature Medicine. 2024. (*equal contribution)

8. Pan, W.*, Zhang, W.*, Zheng, B.*, Camellato, B., Stern, J., Lin, Z., Khodadadi-Jamayran, A., Kim, J., Sommer, P., Khalil, K., Weldon, E., Bai, J., Zhu, Y., Meyn, P., Heguy, A., Mangiola, M., Griesemer, A., Keating, B. J., Montgomery, R. A., Xia, B., Boeke, J. D. Cellular dynamics of pig-to-human kidney xenotransplantation. Med. 2024. (*equal contribution)

9. McCulloch, L. H., Sambasivam, V., Hughes, A. L., Annaluru, N., Ramalingam, S., Fanfani, V., Lobzaev, E., Mitchell, L. A., Richardson, S. M., Cai, J., The Build A Genome Class, Sims, J. J., Bishai, W. R., Cooper, E., Muller, H., Zeller, K., Stracquadanio, G., Steinmetz, L. M., Bader, J. S., Zhang, W.†, Boeke, J. D.†, Chandrasegaran, S.† Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains. Cell Genomics. 2023. († correspondence)

10. Zhang, W., Mitchell, L.A., Bader, J.S., and Boeke, J.D. Synthetic Genomes. Annual Review Biochemistry. 2020.

●  联系方式：

通讯地址：北京市海淀区365买球的网址医学科学楼D224

邮箱：weiminzhang@mail.tsinghua.edu.cn